Search Results - Therapeutics

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Hydrogen Sulfide-Releasing Therapeutics Reduce NSAID Toxicity and Provide Protection During Stroke

Description This technology is a suite of hydrogen sulfide (H2S) prodrugs that has broad applicability for decreasing toxicity during the treatment of inflammation using NSAIDs. In vivo studies have demonstrated reduction of gastrointestinal ulcers, kidney toxicity, and liver toxicity during NSAID use. In separate in vivo studies, these technologies...

Published: 3/24/2025 | Inventor(s): Binghe Wang, Yueqin Zheng

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Category(s): Therapeutics, Research Tool

Anti-Biofilm Agent Effective At Low Doses

Description This technology is a compound and method to break down a Pseudomonas aeruginosa biofilm. Biofilms are clusters of bacteria that are attached to other bacterial cells and to the surface as a slimy coating, often resistant to antibiotics. The cells within the biofilm produce extracellular polymeric matrices which are capable of adhering...

Published: 3/12/2025 | Inventor(s): Charles Derby, Eric Gilbert, Phang-Cheng Tai, Marwa Ahmed

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Category(s): Therapeutics

Highly Effective Therapeutics to Overcome Antibiotic Resistance

Description This technology is a series of small molecules that enhance antibiotic effectiveness in treating bacterial infections. These compounds not only sensitizes resistant bacteria to enable more effective treatment, but also act as an antibiotic adjuvant to allow lower antibiotic doses to be used. The lead compound has been shown to sensitize...

Published: 3/24/2025 | Inventor(s): Binghe Wang, David Boykin, Manjusha Choudhury, Arvind Kumar, Bingchen Yu, Mengyuan Zhu

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Category(s): Therapeutics

Selective Chemotherapeutics That Specifically Target Tumor Cells

Description This technology is a series of synthesized cyanines that display high binding affinity to quadruplex DNA with high selectivity over duplex sequences. Cyanines are a class of small molecules that could be developed as potential G-quadruplex targeting agents. These cyanines have been designed to achieve highly selective binding to DNA G-quadruplexes...

Published: 2/21/2025 | Inventor(s): Maged Henary, W. David Wilson

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Category(s): Therapeutics

Safe, Effective Biofilm Inhibition Without Increasing Antimicrobial Resistance

Description This technology is a series of compounds, derived from Gesho plant, that exhibits remarkable antibiofilm activity while minimizing biocidal effects. These compounds can effectively prevent biofilm formation, offering a safe and effective solution for biofilm inhibition against a wide variety of microbes without increasing antimicrobial...

Published: 3/12/2025 | Inventor(s): Eric Gilbert, Mariya Campbell, Raghda Fathi, Jenail Marshall, Bethany Turner-Livermore

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Category(s): Therapeutics

Low Energy Photosensitizers with Improved Safety and Efficacy for Dermatological Conditions Description

Description This technology is a group of novel photosensitizers used in photodynamic therapy to treat cancer, dermatological conditions, and other cell growth disorders, including elective cosmetic treatments. Photosensitizers are a critical component of photodynamic therapy as they produce a reactive form of oxygen when exposed to a specific wavelength...

Published: 1/24/2025 | Inventor(s): Maged Henary, Kathryn Grant

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Category(s): Therapeutics

Oral Paramyxovirus Therapeutic with Low Toxicity and Reduced Viral Resistance

Description This technology is an RNA polymerase inhibitor therapeutic for use in paramyxoviruses, including parainfluenza, Nipah virus and measles. This allosteric, non-nucleoside inhibitor acts by binding to the polymerase complex to inhibit viral RNA replication and may have lower toxicity than nucleoside polymerase inhibitors. There is currently...

Published: 3/19/2025 | Inventor(s): Richard Plemper, Robert Cox, Benhur Lee

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Category(s): Therapeutics

Highly Effective, Tunable, Intracellular CO Therapeutics

Description This technology is a series of organic carbon monoxide (CO) prodrugs that release the gasotransmitter CO in a controllable fashion in response to various stimuli (pH changes, ROS, enzymes, etc.). CO is a gasotransmitter with critical physiological functions in mammals. Its biological importance is on par with that of nitric oxide (NO),...

Published: 3/24/2025 | Inventor(s): Binghe Wang, Ce Yang

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Category(s): Therapeutics

Highly Effective, Patient-Specific Neuromodulation Therapy

Description This technology is a novel personalized neuromodulation therapy. There are more than 600 neurological disorders affecting patients and they impact an estimated 50 million patients each year in the US alone. In recent years, deep brain stimulation (DBS), which uses the focused delivery of current to the brain to affect neural processes,...

Published: 8/28/2024 | Inventor(s): Vince Calhoun, Robert Gross, Mohammad Sadegh Eslampanah Sendi

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Category(s): Software, Therapeutics

Novel Covid Anti-Viral Therapeutics

Description This technology is a series of small molecules with potent anti-viral effects specifically designed for SARS-CoV-2 infections. The GSU compounds showed remarkable anti-viral activity against SARS-CoV-2 infections without in vivo toxicity in mouse models and exhibiting favorable biopharmaceutical properties, these compounds showcase significant...

Published: 8/28/2024 | Inventor(s): Didier Merlin, Chunhua Yang

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Category(s): Therapeutics

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