Search Results - therapeutics

19 Results

Sort By:

Targeted Therapy for Inflammatory Diseases and Cancer

Description This technology is a biologic therapy that modulates macrophage activity to redirect immune responses, reduces inflammation, and suppresses tumor growth. Preclinical studies in mouse models show that treatment with this technology significantly reduces tumor burden, decreases metastasis spread, and reshapes the tumor microenvironment. These...

Published: 7/18/2025 | Inventor(s): Zhi-Ren Liu, Guangda Peng

Keywords(s):

Category(s): Therapeutics

Highly Effective Monoclonal Antibodies for Gonorrhea Treatment

Description This technology is a series of novel monoclonal antibodies (mAbs) developed to specifically block the growth of N. gonorrhoeae. In preclinical studies, select mAbs not only reduced clinical symptoms and bacterial load in mice but also conferred cross-protection against invasive Neisseria meningitidis (Nme) infection. These findings support...

Published: 7/18/2025 | Inventor(s): Cynthia Cornelissen, Julie Stoudenmire-Saylor

Keywords(s):

Category(s): Therapeutics

Smart ROS-Triggered Prodrug Platform for Cancer and Infectious Disease Treatment

Description This technology is a novel class of ROS (Reactive Oxygen Species)-sensitive linkers and related prodrugs designed for the targeted treatment of cancer and infectious diseases. This technology utilizes the elevated ROS levels present in diseased tissues to selectively activate therapeutic compounds, enabling precise drug release at the site...

Published: 7/18/2025 | Inventor(s): Binghe Wang, Shubham Bansal, Mohammed Kondengadan

Keywords(s):

Category(s): Therapeutics

Powerful Formulation for Respiratory Infection Prevention and Treatment

Description This technology is a set of innovative pharmaceutical formulations that utilize metabolites derived from specific gut microbiota to prevent respiratory infections and enhance immune health. Formulations are available for both oral and intranasal administration, offering flexibility and ease of use. By strengthening the immune system's...

Published: 5/14/2025 | Inventor(s): Andrew Gewirtz, Vu Le Ngo

Keywords(s):

Category(s): Therapeutics

Potent, Safer Respiratory Syncytial Virus Therapeutics

Description This technology is a cutting-edge antiviral technology designed to treat respiratory syncytial virus (RSV) by potently inhibiting RSV RNA synthesis. This technology has shown remarkable efficacy in preclinical mouse models, significantly reducing lung virus load. With the potential for oral administration and reduced toxicity, this breakthrough...

Published: 6/26/2025 | Inventor(s): Richard Plemper, Julien Sourimant

Keywords(s):

Category(s): Therapeutics

Highly Effective Nanobodies to Treat Henipavirus Infections

Description This technology is a series of small molecule therapeutics to treat Henipavirus infections, which is a dangerous group of viruses that cause severe diseases in both humans and animals. These nanobodies are engineered to recognize and bind to specific proteins on Nipah and Hendra viruses, effectively cross-neutralizing different strains...

Published: 4/8/2025 | Inventor(s): Jianliang Xu

Keywords(s):

Category(s): Therapeutics

Highly Effective Small Molecules for Cancer Treatment

Description This technology is a series of innovative small molecules demonstrating significant in-vitro anticancer activity. Isolated from a previously unstudied medicinal plant species, these compounds expand the potential of natural products in drug discovery. Previous studies on related plant species have identified compounds with a broad spectrum...

Published: 7/18/2025 | Inventor(s): Paulos Yohannes, Binghe Wang

Keywords(s):

Category(s): Therapeutics

Hydrogen Sulfide-Releasing Therapeutics Reduce NSAID Toxicity and Provide Protection During Stroke

Description This technology is a suite of hydrogen sulfide (H2S) prodrugs that has broad applicability for decreasing toxicity during the treatment of inflammation using NSAIDs. In vivo studies have demonstrated reduction of gastrointestinal ulcers, kidney toxicity, and liver toxicity during NSAID use. In separate in vivo studies, these technologies...

Published: 6/26/2025 | Inventor(s): Binghe Wang, Yueqin Zheng

Keywords(s):

Category(s): Therapeutics, Research Tool

Anti-Biofilm Agent Effective At Low Doses

Description This technology is a compound and method to break down a Pseudomonas aeruginosa biofilm. Biofilms are clusters of bacteria that are attached to other bacterial cells and to the surface as a slimy coating, often resistant to antibiotics. The cells within the biofilm produce extracellular polymeric matrices which are capable of adhering...

Published: 3/12/2025 | Inventor(s): Charles Derby, Eric Gilbert, Phang-Cheng Tai, Marwa Ahmed

Keywords(s):

Category(s): Therapeutics

Highly Effective Therapeutics to Overcome Antibiotic Resistance

Description This technology is a series of small molecules that enhance antibiotic effectiveness in treating bacterial infections. These compounds not only sensitizes resistant bacteria to enable more effective treatment, but also act as an antibiotic adjuvant to allow lower antibiotic doses to be used. The lead compound has been shown to sensitize...

Published: 6/26/2025 | Inventor(s): Binghe Wang, David Boykin, Manjusha Choudhury, Arvind Kumar, Bingchen Yu, Mengyuan Zhu

Keywords(s):

Category(s): Therapeutics

1 2