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Powerful Formulation for Respiratory Infection Prevention and Treatment

Description This technology is a set of innovative pharmaceutical formulations that utilize metabolites derived from specific gut microbiota to prevent respiratory infections and enhance immune health. Formulations are available for both oral and intranasal administration, offering flexibility and ease of use. By strengthening the immune system's...

Published: 5/14/2025 | Inventor(s): Andrew Gewirtz, Vu Le Ngo

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Category(s): Therapeutics

Potent, Safer Respiratory Syncytial Virus Therapeutics

Description This technology is a cutting-edge antiviral technology designed to treat respiratory syncytial virus (RSV) by potently inhibiting RSV RNA synthesis. This technology has shown remarkable efficacy in preclinical mouse models, significantly reducing lung virus load. With the potential for oral administration and reduced toxicity, this breakthrough...

Published: 5/14/2025 | Inventor(s): Richard Plemper, Julien Sourimant

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Category(s): Therapeutics

Highly Effective Nanobodies to Treat Henipavirus Infections

Description This technology is a series of small molecule therapeutics to treat Henipavirus infections, which is a dangerous group of viruses that cause severe diseases in both humans and animals. These nanobodies are engineered to recognize and bind to specific proteins on Nipah and Hendra viruses, effectively cross-neutralizing different strains...

Published: 4/8/2025 | Inventor(s): Jianliang Xu

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Category(s): Therapeutics

Highly Effective Small Molecules for Cancer Treatment

Description This technology is a series of innovative small molecules demonstrating significant in-vitro anticancer activity. Isolated from a previously unstudied medicinal plant species, these compounds expand the potential of natural products in drug discovery. Previous studies on related plant species have identified compounds with a broad spectrum...

Published: 4/10/2025 | Inventor(s): Paulos Yohannes, Binghe Wang

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Category(s): Therapeutics

Hydrogen Sulfide-Releasing Therapeutics Reduce NSAID Toxicity and Provide Protection During Stroke

Description This technology is a suite of hydrogen sulfide (H2S) prodrugs that has broad applicability for decreasing toxicity during the treatment of inflammation using NSAIDs. In vivo studies have demonstrated reduction of gastrointestinal ulcers, kidney toxicity, and liver toxicity during NSAID use. In separate in vivo studies, these technologies...

Published: 4/8/2025 | Inventor(s): Binghe Wang, Yueqin Zheng

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Category(s): Therapeutics, Research Tool

Anti-Biofilm Agent Effective At Low Doses

Description This technology is a compound and method to break down a Pseudomonas aeruginosa biofilm. Biofilms are clusters of bacteria that are attached to other bacterial cells and to the surface as a slimy coating, often resistant to antibiotics. The cells within the biofilm produce extracellular polymeric matrices which are capable of adhering...

Published: 3/12/2025 | Inventor(s): Charles Derby, Eric Gilbert, Phang-Cheng Tai, Marwa Ahmed

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Category(s): Therapeutics

Highly Effective Therapeutics to Overcome Antibiotic Resistance

Description This technology is a series of small molecules that enhance antibiotic effectiveness in treating bacterial infections. These compounds not only sensitizes resistant bacteria to enable more effective treatment, but also act as an antibiotic adjuvant to allow lower antibiotic doses to be used. The lead compound has been shown to sensitize...

Published: 3/24/2025 | Inventor(s): Binghe Wang, David Boykin, Manjusha Choudhury, Arvind Kumar, Bingchen Yu, Mengyuan Zhu

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Category(s): Therapeutics

Selective Chemotherapeutics That Specifically Target Tumor Cells

Description This technology is a series of synthesized cyanines that display high binding affinity to quadruplex DNA with high selectivity over duplex sequences. Cyanines are a class of small molecules that could be developed as potential G-quadruplex targeting agents. These cyanines have been designed to achieve highly selective binding to DNA G-quadruplexes...

Published: 2/21/2025 | Inventor(s): Maged Henary, W. David Wilson

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Category(s): Therapeutics

Safe, Effective Biofilm Inhibition Without Increasing Antimicrobial Resistance

Description This technology is a series of compounds, derived from Gesho plant, that exhibits remarkable antibiofilm activity while minimizing biocidal effects. These compounds can effectively prevent biofilm formation, offering a safe and effective solution for biofilm inhibition against a wide variety of microbes without increasing antimicrobial...

Published: 3/12/2025 | Inventor(s): Eric Gilbert, Mariya Campbell, Raghda Fathi, Jenail Marshall, Bethany Turner-Livermore

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Category(s): Therapeutics

Low Energy Photosensitizers with Improved Safety and Efficacy for Dermatological Conditions Description

Description This technology is a group of novel photosensitizers used in photodynamic therapy to treat cancer, dermatological conditions, and other cell growth disorders, including elective cosmetic treatments. Photosensitizers are a critical component of photodynamic therapy as they produce a reactive form of oxygen when exposed to a specific wavelength...

Published: 1/24/2025 | Inventor(s): Maged Henary, Kathryn Grant

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Category(s): Therapeutics

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