Search Results - therapeutics

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Targeted Oral Nanotherapy for IBD Treatment and Recovery

Description This technology is a lipid nanoparticle formulation composed of a proprietary blend of three major lipids identified in ginger-derived nanoparticles (GDNPs 2), isolated from edible ginger. These nanoparticles are orally administered, non-toxic, and selectively target the colon. Designed specifically for colon-specific delivery, these nanoparticles...

Published: 10/28/2025 | Inventor(s): Didier Merlin, Chunhua Yang

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Category(s): Therapeutics, Material

Next-Generation Immunotherapy to Overcome Tumor Resistance

Description This technology is a next-generation oncolytic virus (OV) designed to address the critical challenge of tumor resistance in cancer therapy. Built on the vesicular stomatitis virus (VSV) platform, this engineered OV is capable of inducing strong, tumor-selective cell death even in apoptosis-resistant cancers. In preclinical studies, this...

Published: 10/28/2025 | Inventor(s): Ming Luo

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Category(s): Therapeutics

Innovative Small Molecules for Safe Weight Loss and Lean Muscle Mass Preservation

Description This technology is a class of small molecules designed to treat obesity and obesity-related metabolic dysfunctions, including type 2 diabetes. These molecules show significant weight loss in preclinical mouse models without suppressing appetite or reducing physical activity. Importantly, they preserve lean muscle mass while reducing fat,...

Published: 10/28/2025 | Inventor(s): Chong Hyun Shin

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Category(s): Therapeutics

Targeted Therapy for Inflammatory Diseases and Cancer

Description This technology is a biologic therapy that modulates macrophage activity to redirect immune responses, reduces inflammation, and suppresses tumor growth. Preclinical studies in mouse models show that treatment with this technology significantly reduces tumor burden, decreases metastasis spread, and reshapes the tumor microenvironment. These...

Published: 7/18/2025 | Inventor(s): Zhi-Ren Liu, Guangda Peng

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Category(s): Therapeutics

Highly Effective Monoclonal Antibodies for Gonorrhea Treatment

Description This technology is a series of novel monoclonal antibodies (mAbs) developed to specifically block the growth of N. gonorrhoeae. In preclinical studies, select mAbs not only reduced clinical symptoms and bacterial load in mice but also conferred cross-protection against invasive Neisseria meningitidis (Nme) infection. These findings support...

Published: 7/18/2025 | Inventor(s): Cynthia Cornelissen, Julie Stoudenmire-Saylor

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Category(s): Therapeutics

Smart ROS-Triggered Prodrug Platform for Cancer and Infectious Disease Treatment

Description This technology is a novel class of ROS (Reactive Oxygen Species)-sensitive linkers and related prodrugs designed for the targeted treatment of cancer and infectious diseases. This technology utilizes the elevated ROS levels present in diseased tissues to selectively activate therapeutic compounds, enabling precise drug release at the site...

Published: 7/18/2025 | Inventor(s): Binghe Wang, Shubham Bansal, Mohammed Kondengadan

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Category(s): Therapeutics

Powerful Formulation for Respiratory Infection Prevention and Treatment

Description This technology is a set of innovative pharmaceutical formulations that utilize metabolites derived from specific gut microbiota to prevent respiratory infections and enhance immune health. Formulations are available for both oral and intranasal administration, offering flexibility and ease of use. By strengthening the immune system's...

Published: 5/14/2025 | Inventor(s): Andrew Gewirtz, Vu Le Ngo

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Category(s): Therapeutics

Potent, Safer Respiratory Syncytial Virus Therapeutics

Description This technology is a cutting-edge antiviral technology designed to treat respiratory syncytial virus (RSV) by potently inhibiting RSV RNA synthesis. This technology has shown remarkable efficacy in preclinical mouse models, significantly reducing lung virus load. With the potential for oral administration and reduced toxicity, this breakthrough...

Published: 6/26/2025 | Inventor(s): Richard Plemper, Julien Sourimant

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Category(s): Therapeutics

Highly Effective Nanobodies to Treat Henipavirus Infections

Description This technology is a series of small molecule therapeutics to treat Henipavirus infections, which is a dangerous group of viruses that cause severe diseases in both humans and animals. These nanobodies are engineered to recognize and bind to specific proteins on Nipah and Hendra viruses, effectively cross-neutralizing different strains...

Published: 4/8/2025 | Inventor(s): Jianliang Xu

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Category(s): Therapeutics

Highly Effective Small Molecules for Cancer Treatment

Description This technology is a series of innovative small molecules demonstrating significant in-vitro anticancer activity. Isolated from a previously unstudied medicinal plant species, these compounds expand the potential of natural products in drug discovery. Previous studies on related plant species have identified compounds with a broad spectrum...

Published: 10/15/2025 | Inventor(s): Paulos Yohannes, Binghe Wang

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Category(s): Therapeutics

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