Search Results - binghe+wang

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Hydrogen Sulfide-Releasing Therapeutics Reduce NSAID Toxicity and Provide Protection During Stroke

Description This technology is a suite of hydrogen sulfide (H2S) prodrugs that has broad applicability for decreasing toxicity during the treatment of inflammation using NSAIDs. In vivo studies have demonstrated reduction of gastrointestinal ulcers, kidney toxicity, and liver toxicity during NSAID use. In separate in vivo studies, these technologies...

Published: 4/8/2025 | Inventor(s): Binghe Wang, Yueqin Zheng

Keywords(s):

Category(s): Therapeutics, Research Tool

Highly Effective Therapeutics to Overcome Antibiotic Resistance

Description This technology is a series of small molecules that enhance antibiotic effectiveness in treating bacterial infections. These compounds not only sensitizes resistant bacteria to enable more effective treatment, but also act as an antibiotic adjuvant to allow lower antibiotic doses to be used. The lead compound has been shown to sensitize...

Published: 3/24/2025 | Inventor(s): Binghe Wang, David Boykin, Manjusha Choudhury, Arvind Kumar, Bingchen Yu, Mengyuan Zhu

Keywords(s):

Category(s): Therapeutics

Highly Effective, Tunable, Intracellular CO Therapeutics

Description This technology is a series of organic carbon monoxide (CO) prodrugs that release the gasotransmitter CO in a controllable fashion in response to various stimuli (pH changes, ROS, enzymes, etc.). CO is a gasotransmitter with critical physiological functions in mammals. Its biological importance is on par with that of nitric oxide (NO),...

Published: 3/24/2025 | Inventor(s): Binghe Wang, Ce Yang

Keywords(s):

Category(s): Therapeutics

Highly Effective Therapeutics for Acute Lymphocytic Leukemia

Description This technology is a series of small molecule inhibitors designed to treat Acute Lymphocytic Leukemia (ALL), a rapidly progressing cancer affecting lymphoid blood cells and bone marrow. The disease progresses rapidly and creates immature blood cells rather than mature ones. The leukemia cells are carried in the bloodstream to other organs...

Published: 8/28/2024 | Inventor(s): Binghe Wang, Ravi Tripathi, Xiaoxiao Yang

Keywords(s):

Category(s): Therapeutics