Hydrogen Sulfide-Releasing Therapeutics Reduce NSAID Toxicity and Provide Protection During Stroke

Description

This technology is a suite of hydrogen sulfide (H2S) prodrugs that has broad applicability for decreasing toxicity during the treatment of inflammation using NSAIDs. In vivo studies have demonstrated reduction of gastrointestinal ulcers, kidney toxicity, and liver toxicity during NSAID use. In separate in vivo studies, these technologies reduced brain tissue damage in ischemic stroke. These H2S prodrugs release H2S in response to biologically relevant triggers. In contrast to H2S prodrugs in development, these technologies offer controlled, tunable release and improved biocompatibility. This technology capitalizes on the role of H2S as a gasotransmitter and naturally occurring signaling molecule. These technologies could also be used as research tools.

Benefits

Controlled release – H2S prodrug is released in the presence of biologically relevant triggers
Reduced toxicity – Controlled release of H2S prodrug prevents excessive H2S levels
Biocompatibility – Simple chemical process minimizes byproducts
Tunable release – Changes to chemical scaffold can change the rate of H2S prodrug release
Flexibility – Release can be triggered chemically or enzymatically in response to esterases, proteases, phosphatase, glycosidase
No external stimuli – UV light or other external trigger is not needed
Benefit No consumption of biological nutrients – Avoids disruption of biological equilibrium

Applications

Reduction of brain tissue damage during ischemic stroke
Protection from ulcers and kidney and liver toxicity during NSAID use
Protection against organ toxicity or damage from other causes
Other H2S-deficient states including
- Cardiovascular conditions
- • Ophthalmic conditions
- • Neurological conditions
- • Diabetes
- • Hypertension
- • Asthma
- • Inflammation
- • Hypertension
- • Gastric injury
- • Irritable bowel syndrome
- • Kidney dysfunction
- • Sepsis
- • Ischemia
- • Respiratory distress syndrome
- • Thrombosis
- • Cancer
Research tools